August 28, 2025
4 min read
New Cell Transplant for Type 1 Diabetes Sidesteps Need for Immunosuppressants
Scientists treated a person’s type 1 diabetes with genetically modified insulin-producing cells that evaded immune system attacks. This is the first therapy for the condition that does not require immunosuppressant drugs
Insulin-producing cells can be genetically modified to hide from the immune system.
Jim Dowdalls/Science Source
People with type 1 diabetes must constantly rely on insulin injections or pumps, usually for the rest of their life after diagnosis. The autoimmune disease destroys the cells that produce the hormone, which is crucial to keeping blood sugar in check. But now research suggests a new therapy could finally allow people with type 1 diabetes to make insulin on their own.
A 42-year-old man who has lived most of his life with type 1 diabetes has become the first human to receive a transplant of genetically modified insulin-producing cells that can slip past the immune system’s mistaken attacks. This marks the first pancreatic cell transplant in a human to sidestep the need for immunosuppressant drugs—and it might even lead to a future cure for the disease, researchers say.
“This is the most exciting moment of my scientific career,” says cell biologist Per-Ola Carlsson of Uppsala University in Sweden, who helped develop the procedure. The new treatment, he says, “opens the future possibility of treating not only diabetes but other autoimmune diseases.”
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Scientists injected nearly 80 million genetically tweaked cells into the participant’s forearm muscle, and 12 weeks later the cells were still alive and producing insulin. The recipient did require additional insulin injections—but the injected cells showed no signs of rejection, which the researchers say is a major step forward. The results were reported this month in the New England Journal of Medicine.
About two million people in the U.S. live with type 1 diabetes, which typically requires an intensive regimen of insulin injections and blood sugar monitoring. If their blood sugar runs amok, people face severe risks, including heart attacks, nerve damage,…
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