Disease name: Xeroderma pigmentosum (XP)
Affected populations: Xeroderma pigmentosum is a rare genetic disorder that makes people’s skin extremely sensitive to the harmful effects of ultraviolet (UV) light. Both males and females can develop XP, and it can affect people from different ethnic backgrounds.
XP is estimated to affect approximately 1 person per million in the United States, but it is more common in other regions of the world, including Japan, North Africa and the Middle East. For example, in Japan, around 45 people per million are estimated to have XP.
Related: Simple blood test could reveal likelihood of deadly skin cancer returning, study suggests
Causes: XP is caused by gene mutations that prevent DNA from being repaired after it’s damaged by UV radiation, which is present in sunlight and some kinds of artificial lighting, including that used for tanning beds. The unrepaired DNA accumulates within cells, triggering a plethora of different symptoms.
Scientists have identified eight different gene mutations that are tied to the development of XP; the most common of these, at least in the U.S., is a mutation in a gene called XPC. This gene codes for an enzyme that is key for detecting DNA damage, and the mutation renders the protein unable to do its job.
XP is an autosomal recessive condition, which means that people must inherit two copies of a faulty gene — one from each parent — in order to develop it.
Symptoms: Symptoms of XP usually begin in infancy or early childhood. People with the condition typically burn very easily in the sun — around half of children with XP are susceptible to severe sunburn within only a few minutes of exposure to sunlight.
Patients with XP may also develop freckles before the age of 2 in parts of the body that are commonly exposed to daylight, such as the face, arms and lips. In addition, their eyes are often very sensitive to DNA damage caused by bright light. Repeated exposure to sunlight may additionally cause the skin to become dry, thinner and have a mixture of darker and lighter regions.
Patients with XP are up to 2,000 times more likely to develop melanoma, a type of skin cancer for which UV exposure is a major risk factor. Without protection from UV light, people with…
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